Mechanisms of Degradation for Polydisulfides: Main Chain Scission, Self-Immolation, Or Chain Transfer Depolymerization Kristensen, M. M.; Løvschall, K. B.; Zelikin, A. N., Mechanisms of Degradation…
“Antibody-Drug Conjugates to Treat Bacterial Biofilms viaTargeting and Extracellular Drug Release” https://doi.org/10.1002/advs.202301340 Abstract The treatment of implant-associated bacterial infections and biofilms is an urgent medical…
“Chemical zymogens: specificity and steroidal control ofreactivation” https://doi.org/10.1002/cbic.202300304 Abstract: Activation and masking of enzymatic activity on demand is of the highest importance in nature. It…
Signal transduction across biological membranes is among the most important evolutionary achievements. Herein, for the design of artificial cells, weengineer fully synthetic receptors with the…
“Potentiation of Drug Toxicity through Virus Latency Reversal Promotes Preferential Elimination of HIV Infected Cells” https://doi.org/10.1002/adtp.202200113 Eliminating latently infected cells is a highly challenging, indispensable…
“Chemical zymogens for the protein cysteinome“ https://doi.org/10.1038/s41467-022-32609-1 We present three classes of chemical zymogens established around the protein cysteinome. In each case, the cysteine thiol…
Our novel work in protein modification “Per-glycosylation of the Surface-Accessible Lysines: One-Pot Aqueous Route to Stabilized Proteins with Native Activity” has been published in ChemBioChem.…
Our work in “Chemical (neo)glycosylation of biological drugs” has been published in Advanced Drug Delivery Reviews. Biological drugs, specifically proteins and peptides, are a privileged…
We join the fight against COVID-19 with a collaboration with Jan Münch about repurposing of heparin for prevention and treatment against the virus published in…
Our work on “Molecular, Macromolecular, and Supramolecular Glucuronide Prodrugs: Lead Identified for Anticancer Prodrug Monotherapy” has been recently published in Angewande Chemie. In this work,…