Publications

"Synthetic Polymer with a Structure-Driven Hepatic Deposition and Curative Pharmacological Activity in Hepatic Cells"
Riber, Camilla Frich; Andersen, Anna Halling Folkmar; Rolskov, Lærke Anegaard; Zuwala, Kaja; Gajda, Paulina; Løvschall, Kaja Borup; Dagnæs-Hansen, Frederik; Banda, Dominic H.; Pietschmann, Thomas; Tolstrup, Martin; Zelikin, Alexander N.
ACS Macro Letters 2017, (), 935-940

"Enzyme Prodrug Therapy Engineered into Electrospun Fibers with Embedded Liposomes for Controlled, Localized Synthesis of Therapeutics"
Chandrawati, Rona; Olesen, Morten T. J.; Marini, Thatiane C. C.; Bisra, Gurpal; Guex, Anne Géraldine; de Oliveira, Marcelo G.; Zelikin, Alexander N.; Stevens, Molly M.
Advanced Healthcare Materials , (), 1700385-n/a

"Prodrugs in medicinal chemistry and enzyme prodrug therapies"
Walther, Raoul; Rautio, Jarkko; Zelikin, Alexander N.
Advanced Drug Delivery Reviews , (),

"Recent advances in macromolecular prodrugs"
Riber, Camilla Frich; Zelikin, Alexander N.
Current Opinion in Colloid & Interface Science 2017, 31(), 1-9

"Preparation, single-molecule manipulation and energy transfer investigation of a polyfluorene-graft-DNA polymer"
Madsen, Mikael; Christensen, Rasmus S.; Krissanaprasit, Abhichart; Bakke, Mette R.; Riber, Camilla F.; Nielsen, Karina S.; Zelikin, Alexander; Gothelf, Kurt Vesterager
Chemistry – A European Journal , (), n/a-n/a

"Substrate Mediated Enzyme Prodrug Therapy"
Fejerskov, Betina; Jarlstad Olesen, Morten T.; Zelikin, Alexander N.
Advanced Drug Delivery Reviews 2017, (),

"Localized and Controlled Delivery of Nitric Oxide to the Conventional Outflow Pathway via Enzyme Biocatalysis: Toward Therapy for Glaucoma"
Chandrawati, Rona; Chang, Jason Y. H.; Reina-Torres, Ester; Jumeaux, Coline; Sherwood, Joseph M.; Stamer, W. Daniel; Zelikin, Alexander N.; Overby, Darryl R.; Stevens, Molly M.
Advanced Materials 2017, 29(16), 1604932

"Macromolecular Prodrugs of Ribavirin: Structure–Function Correlation as Inhibitors of Influenza Infectivity"
Riber, Camilla Frich; Hinton, Tracey M.; Gajda, Paulina; Zuwala, Kaja; Tolstrup, Martin; Stewart, Cameron; Zelikin, Alexander N.
Molecular Pharmaceutics 2016, 14(1), 234–241

"Materials and methods for delivery of biological drugs"
Zelikin, Alexander N.; Ehrhardt, Carsten; Healy, Anne Marie
Nat Chem 2016, 8(11), 997-1007

"Albumin–Polymer–Drug Conjugates: Long Circulating, High Payload Drug Delivery Vehicles"
Smith, Anton A. A.; Zuwala, Kaja; Pilgram, Oliver; Johansen, Karen Singers; Tolstrup, Martin; Dagnæs-Hansen, Frederik; Zelikin, Alexander N.
ACS Macro Letters 2016, 5(10), 1089-1094

"Triple Activity of Lamivudine Releasing Sulfonated Polymers against HIV-1"
Danial, Maarten; Andersen, Anna Halling Folkmar; Żuwała, Kaja; Cosson, Steffen; Riber, Camilla Frich; Smith, Anton A. A.; Tolstrup, Martin; Moad, Graeme; Zelikin, Alexander N.; Postma, Almar
Molecular Pharmaceutics 2016, 13(7), 2397-2410

"Polyanionic Macromolecular Prodrugs of Ribavirin: Antiviral Agents with a Broad Spectrum of Activity"
Hinton, Tracey M.; Zuwala, Kaja; Deffrasnes, Celine; Todd, Shawn; Shi, Shuning; Marsh, Glenn A.; Dearnley, Megan; Wohl, Benjamin M.; Tolstrup, Martin; Zelikin, Alexander N.
Advanced Healthcare Materials 2016, 5(5), 534-540

"HIV anti-latency treatment mediated by macromolecular prodrugs of histone deacetylase inhibitor, panobinostat"
Zuwala, Kaja; Smith, Anton; Tolstrup, Martin; Zelikin, Alexander
Chemical Science 2016, 7(3), 2353-2358

"Tools of gene transfer applied to the intracellular delivery of non-nucleic acid polyanionic drugs"
Kryger, Mille B. L.; Pedersen, Søren L.; Wohl, Benjamin M.; Zelikin, Alexander N.
Chemical Communications 2016, 52(5), 889-891

"Phospholipid—polymer amphiphile hybrid assemblies and their interaction with macrophages"
Panneerselvam, Karthiga; Lynge, Martin E.; Riber, Camilla Frich; Mena-Hernando, Sofia; Smith, Anton A. A.; Goldie, Kenneth N.; Zelikin, Alexander N.; Städler, Brigitte
2015, 9(5), 052610

"Routing of individual polymers in designed patterns"
Knudsen, Jakob Bach; Liu, Lei; Bank Kodal, Anne Louise; Madsen, Mikael; Li, Qiang; Song, Jie; Woehrstein, Johannes B.; Wickham, Shelley F. J.; Strauss, Maximilian T.; Schueder, Florian; Vinther, Jesper; Krissanaprasit, Abhichart; Gudnason, Daniel; Smith, Anton Allen Abbotsford; Ogaki, Ryosuke; Zelikin, Alexander N.; Besenbacher, Flemming; Birkedal, Victoria; Yin, Peng; Shih, William M.; Jungmann, Ralf; Dong, Mingdong; Gothelf, Kurt V.
Nat Nano 2015, 10(10), 892-898

"Self-Immolative Linkers Literally Bridge Disulfide Chemistry and the Realm of Thiol-Free Drugs"
Riber, Camilla Frich; Smith, Anton A. A.; Zelikin, Alexander N.
Advanced Healthcare Materials 2015, 4(12), 1887-1890

"Micro-structured, spontaneously eroding hydrogels accelerate endothelialization through presentation of conjugated growth factors"
Jensen, Bettina E. B.; Edlund, Katrine; Zelikin, Alexander N.
2015, 49(0), 113-124

"Macromolecular (pro)drugs with concurrent direct activity against the hepatitis C virus and inflammation"
Wohl, Benjamin M.; Smith, Anton A. A.; Jensen, Bettina E. B.; Zelikin, Alexander N.
2014, 196(0), 197-207

"Disulfide reshuffling triggers the release of a thiol-free anti-HIV agent to make up fast-acting, potent macromolecular prodrugs"
Kock, Anders; Zuwala, Kaja; Smith, Anton A. A.; Ruiz-Sanchis, Pau; Wohl, Benjamin M.; Tolstrup, Martin; Zelikin, Alexander N.
Chemical Communications 2014, 50(93), 14498-14500

"Macromolecular prodrugs of ribavirin: towards a treatment for co-infection with HIV and HCV"
Smith, Anton A. A.; Zuwala, Kaja; Kryger, Mille B. L.; Wohl, Benjamin M.; Guerrero-Sanchez, Carlos; Tolstrup, Martin; Postma, Almar; Zelikin, Alexander N.
Chemical Science 2015, 6(1), 264-269

"Highly Active Macromolecular Prodrugs Inhibit Expression of the Hepatitis C Virus Genome in the Host Cells"
Ruiz-Sanchis, Pau; Wohl, Benjamin M.; Smith, Anton A. A.; Zuwala, Kaja; Melchjorsen, Jesper; Tolstrup, Martin; Zelikin, Alexander N.
Advanced Healthcare Materials 2015, 4(1), 65-68

"Macromolecular (pro)drugs in antiviral research"
Smith, Anton A. A.; Kryger, Mille B. L.; Wohl, Benjamin M.; Ruiz-Sanchis, Pau; Zuwala, Kaja; Tolstrup, Martin; Zelikin, Alexander N.
Polymer Chemistry 2014, 5(22), 6407-6425

"Enzyme Prodrug Therapy Engineered into Biomaterials"
Mendes, Ana C.; Zelikin, Alexander N.
2014, 24(33), 5202-5210

"Polymers Fight HIV: Potent (Pro)Drugs Identified Through Parallel Automated Synthesis"
Zuwala, Kaja; Smith, Anton A. A.; Postma, Almar; Guerrero-Sanchez, Carlos; Ruiz-Sanchis, Pau; Melchjorsen, Jesper; Tolstrup, Martin; Zelikin, Alexander N.
Advanced Healthcare Materials 2015, 4(1), 46-50

"Cholesterol Modification of (Bio)Polymers Using UV-Vis Traceable Chemistry in Aqueous Solutions"
Rasmussen, Kasper F.; Smith, Anton A. A.; Ruiz-Sanchis, Pau; Edlund, Katrine; Zelikin, Alexander N.
Macromolecular Bioscience 2014, 14(1), 33-44

"Biocatalytic polymer thin films: optimization of the multilayered architecture towards in situ synthesis of anti-proliferative drugs"
Andreasen, Sidsel O.; Fejerskov, Betina; Zelikin, Alexander N.
Nanoscale 2014, 6(8), 4131-4140

"Macromolecular Prodrugs of Ribavirin: Concerted Efforts of the Carrier and the Drug"
Smith, Anton A. A.; Wohl, Benjamin M.; Kryger, Mille B. L.; Hedemann, Natasha; Guerrero-Sanchez, Carlos; Postma, Almar; Zelikin, Alexander N.
Advanced Healthcare Materials 2014, 3(9), 1404-1407

"Biocatalytic Polymer Coatings: On-Demand Drug Synthesis and Localized Therapeutic Effect under Dynamic Cell Culture Conditions"
Fejerskov, Betina; Jensen, Najah B. S.; Teo, Boon M.; Städler, Brigitte; Zelikin, Alexander N.
Small 2014, 10(7), 1314-1324

"The narrow therapeutic window of ribavirin as an inhibitor of nitric oxide synthesis is broadened by macromolecular prodrugs"
Wohl, Benjamin M.; Smith, Anton A. A.; Kryger, Mille B. L.; Zelikin, Alexander N.
2013, 14(11), 3916–3926

"Macromolecular Prodrugs for Controlled Delivery of Ribavirin"
Kryger, Mille B. L.; Smith, Anton A. A.; Wohl, Benjamin M.; Zelikin, Alexander N.
Macromolecular Bioscience 2014, 14(2), 173-185

"Lipogels: Surface-Adherent Composite Hydrogels Assembled from Poly(Vinyl Alcohol) and Liposomes"
Jensen, Bettina; Hosta-Rigau, Leticia; Spycher, Philipp; Reimhult, Erik; Stadler, Brigitte; Zelikin, Alexander
Nanoscale 2013, 5(), 6758-6766

"Poly(vinyl alcohol) physical hydrogel nanoparticles, not polymer solutions, exert inhibition of nitric oxide synthesis in cultured macrophages"
Andreasen, Sidsel; Chong, Siow-Feng; Wohl, Benjamin M.; Goldie, Kenneth N.; Zelikin, Alexander N.
2013, 14(5), 1687–1695

"Liposomal Templating, Association with Mammalian Cells, and Cytotoxicity of Poly(vinyl alcohol) Physical Hydrogel Nanoparticles"
Andreasen, Sidsel Ø; Chong, Siow-Feng; Kryger, Mille B. L.; Jensen, Bettina E. B.; Postma, Almar; Alves, Marie-Helene; Städler, Brigitte; Goldie, Kenneth N.; Zelikin, Alexander N.
2013, 5(8), 2967–2975

"Macromolecular Prodrugs of Ribavirin Combat Side Effects and Toxicity with No Loss of Activity of the Drug"
Kryger, Mille; Wohl, Benjamin; Smith, Anton; Zelikin, Alexander
Chemical Communications 2013, 49(), 2643-2645

"Bioresorbable Surface Adhered Enzymatic Microreactors Based on Physical Hydrogels of Poly(vinyl alcohol)"
Fejerskov, Betina; Smith, Anton A. A.; Jensen, Bettina E. B.; Hussmann, Thomas; Zelikin, Alexander N.
2013, 29(1), 344–354

"Microstructured, Functional PVA Hydrogels through Bioconjugation with Oligopeptides under Physiological Conditions"
Chong, Siow-Feng; Smith, Anton A. A.; Zelikin, Alexander N.
Small 2013, 9(6), 942–950

"Substrate Mediated Enzyme Prodrug Therapy"
Fejerskov, Betina; Zelikin, Alexander N.
2012, 7(11), e49619

"Engineering Surface Adhered Poly(vinyl alcohol) Physical Hydrogels as Enzymatic Microreactors"
Fejerskov, Betina; Jensen, Bettina E. B.; Jensen, Najah B. S.; Chong, Siow-Feng; Zelikin, Alexander N.
2012, 4(9), 4981–4990

"Surface adhered poly(vinyl alcohol) physical hydrogels as tools for rational design of intelligent biointerfaces"
Jensen, B. E. B.; Alves, M. H.; Fejerskov, B.; Städler, B.; Zelikin, A. N.
2012, 8(17), 4625-4634

"Intelligent Polymer Thin Films and Coatings for Drug Delivery"
Zelikin, Alexander N.; Städler, Brigitte
2012, (), 243-290

"Macromolecular design of poly(vinyl alcohol) by RAFT polymerization"
Smith, A. A. A.; Hussmann, T.; Elich, J.; Postma, A.; Alves, M. H.; Zelikin, A. N.
Polymer Chemistry 2012, 3(1), 85-88

"Poly(vinyl alcohol) physical hydrogels: New vista on a long serving biomaterial"
Alves, M. H.; Jensen, B. E. B.; Smith, A. A. A.; Zelikin, A. N.
Macromolecular Bioscience 2011, 11(10), 1293-1313

"Poly(vinyl alcohol) physical hydrogels: Noncryogenic stabilization allows nano- and microscale materials design"
Jensen, B. E. B.; Smith, A. A. A.; Fejerskov, B.; Postma, A.; Senn, P.; Reimhult, E.; Pla-Roca, M.; Isa, L.; Sutherland, D. S.; Städler, B.; Zelikin, A. N.
2011, 27(16), 10216-10223

"Exploiting fluorescent polymers to probe the self-assembly of virus-like particles"
Cadena-Nava, R. D.; Hu, Y.; Garmann, R. F.; Ng, B.; Zelikin, A. N.; Knobler, C. M.; Gelbart, W. M.
2011, 115(10), 2386-2391

"A critical look at multilayered polymer capsules in biomedicine: Drug carriers, artificial organelles, and cell mimics"
Städler, B.; Price, A. D.; Zelikin, A. N.
2011, 21(1), 14-28

"Poly(methacrylic acid) polymer hydrogel capsules: Drug carriers, sub-compartmentalized microreactors, artificial organelles"
Zelikin, A. N.; Städler, B.; Price, A. D.
Small 2010, 6(20), 2201-2207

"Drug releasing polymer thin films: New era of surface-mediated drug delivery"
Zelikin, A. N.
2010, 4(5), 2494-2509