<?xml version="1.0" encoding="UTF-8" ?><xml><records><record><database name="Alex2015.enl" path="\\ad.nfit.au.dk\NFDFS\Users\riber\Documents\Webpage\literature\Alex2015.enl">Alex2015.enl</database><source-app name="EndNote" version="16.0">EndNote</source-app><rec-number>7</rec-number><foreign-keys><key app="EN" db-id="2zevtz9fir00z3e95tbxsv92f25x99p2zrz2">7</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Panneerselvam, Karthiga</style></author><author><style face="normal" font="default" size="100%">Lynge, Martin E.</style></author><author><style face="normal" font="default" size="100%">Riber, Camilla Frich</style></author><author><style face="normal" font="default" size="100%">Mena-Hernando, Sofia</style></author><author><style face="normal" font="default" size="100%">Smith, Anton A. A.</style></author><author><style face="normal" font="default" size="100%">Goldie, Kenneth N.</style></author><author><style face="normal" font="default" size="100%">Zelikin, Alexander N.</style></author><author><style face="normal" font="default" size="100%">Städler, Brigitte</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phospholipid—polymer amphiphile hybrid assemblies and their interaction with macrophages</style></title><secondary-title><style face="normal" font="default" size="100%">Biomicrofluidics</style></secondary-title></titles><periodical><full-title><style face="normal" font="default" size="100%">Biomicrofluidics</style></full-title></periodical><pages><style face="normal" font="default" size="100%">052610</style></pages><volume><style face="normal" font="default" size="100%">9</style></volume><number><style face="normal" font="default" size="100%">5</style></number><keywords><keyword><style face="normal" font="default" size="100%">adhesion</style></keyword><keyword><style face="normal" font="default" size="100%">intelligent materials</style></keyword><keyword><style face="normal" font="default" size="100%">biomembrane transport</style></keyword><keyword><style face="normal" font="default" size="100%">coatings</style></keyword><keyword><style face="normal" font="default" size="100%">nanofabrication</style></keyword><keyword><style face="normal" font="default" size="100%">evaporation</style></keyword><keyword><style face="normal" font="default" size="100%">surface chemistry</style></keyword><keyword><style face="normal" font="default" size="100%">solvation</style></keyword><keyword><style face="normal" font="default" size="100%">thermodynamics</style></keyword><keyword><style face="normal" font="default" size="100%">materials preparation</style></keyword><keyword><style face="normal" font="default" size="100%">polymer blends</style></keyword><keyword><style face="normal" font="default" size="100%">hydrophilicity</style></keyword><keyword><style face="normal" font="default" size="100%">biomedical materials</style></keyword><keyword><style face="normal" font="default" size="100%">adsorption</style></keyword><keyword><style face="normal" font="default" size="100%">hydrophobicity</style></keyword><keyword><style face="normal" font="default" size="100%">toxicology</style></keyword><keyword><style face="normal" font="default" size="100%">drug delivery systems</style></keyword><keyword><style face="normal" font="default" size="100%">biomechanics</style></keyword><keyword><style face="normal" font="default" size="100%">stress effects</style></keyword><keyword><style face="normal" font="default" size="100%">nanocomposites</style></keyword><keyword><style face="normal" font="default" size="100%">nanomedicine</style></keyword></keywords><dates><year><style face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style face="normal" font="default" size="100%">34</style></date></pub-dates></dates><urls><related-urls><url><style face="normal" font="default" size="100%">http://scitation.aip.org/content/aip/journal/bmf/9/5/10.1063/1.4929405</style></url></related-urls><pdf-urls><url>internal-pdf://pnipam_small-0863482880/pnipam_small.png</url></pdf-urls></urls><electronic-resource-num><style face="normal" font="default" size="100%">doi:http://dx.doi.org/10.1063/1.4929405</style></electronic-resource-num></record><record><database name="Alex2015.enl" path="\\ad.nfit.au.dk\NFDFS\Users\riber\Documents\Webpage\literature\Alex2015.enl">Alex2015.enl</database><source-app name="EndNote" version="16.0">EndNote</source-app><rec-number>14</rec-number><foreign-keys><key app="EN" db-id="2zevtz9fir00z3e95tbxsv92f25x99p2zrz2">14</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Knudsen, Jakob Bach</style></author><author><style face="normal" font="default" size="100%">Liu, Lei</style></author><author><style face="normal" font="default" size="100%">Bank Kodal, Anne Louise</style></author><author><style face="normal" font="default" size="100%">Madsen, Mikael</style></author><author><style face="normal" font="default" size="100%">Li, Qiang</style></author><author><style face="normal" font="default" size="100%">Song, Jie</style></author><author><style face="normal" font="default" size="100%">Woehrstein, Johannes B.</style></author><author><style face="normal" font="default" size="100%">Wickham, Shelley F. J.</style></author><author><style face="normal" font="default" size="100%">Strauss, Maximilian T.</style></author><author><style face="normal" font="default" size="100%">Schueder, Florian</style></author><author><style face="normal" font="default" size="100%">Vinther, Jesper</style></author><author><style face="normal" font="default" size="100%">Krissanaprasit, Abhichart</style></author><author><style face="normal" font="default" size="100%">Gudnason, Daniel</style></author><author><style face="normal" font="default" size="100%">Smith, Anton Allen Abbotsford</style></author><author><style face="normal" font="default" size="100%">Ogaki, Ryosuke</style></author><author><style face="normal" font="default" size="100%">Zelikin, Alexander N.</style></author><author><style face="normal" font="default" size="100%">Besenbacher, Flemming</style></author><author><style face="normal" font="default" size="100%">Birkedal, Victoria</style></author><author><style face="normal" font="default" size="100%">Yin, Peng</style></author><author><style face="normal" font="default" size="100%">Shih, William M.</style></author><author><style face="normal" font="default" size="100%">Jungmann, Ralf</style></author><author><style face="normal" font="default" size="100%">Dong, Mingdong</style></author><author><style face="normal" font="default" size="100%">Gothelf, Kurt V.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Routing of individual polymers in designed patterns</style></title><secondary-title><style face="normal" font="default" size="100%">Nat Nano</style></secondary-title></titles><periodical><full-title><style face="normal" font="default" size="100%">Nat Nano</style></full-title></periodical><pages><style face="normal" font="default" size="100%">892-898</style></pages><volume><style face="normal" font="default" size="100%">10</style></volume><number><style face="normal" font="default" size="100%">10</style></number><dates><year><style face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style face="normal" font="default" size="100%">33</style></date></pub-dates></dates><publisher><style face="normal" font="default" size="100%">Nature Publishing Group</style></publisher><isbn><style face="normal" font="default" size="100%">1748-3387</style></isbn><abstract><style face="normal" font="default" size="100%">Synthetic polymers are ubiquitous in the modern world, but our ability to exert control over the molecular conformation of individual polymers is very limited. In particular, although the programmable self-assembly of oligonucleotides and proteins into artificial nanostructures has been demonstrated, we currently lack the tools to handle other types of synthetic polymers individually and thus the ability to utilize and study their single-molecule properties. Here we show that synthetic polymer wires containing short oligonucleotides that extend from each repeat can be made to assemble into arbitrary routings. The wires, which can be more than 200 nm in length, are soft and bendable, and the DNA strands allow individual polymers to self-assemble into predesigned routings on both two- and three-dimensional DNA origami templates. The polymers are conjugated and potentially conducting, and could therefore be used to create molecular-scale electronic or optical wires in arbitrary geometries.</style></abstract><work-type><style face="normal" font="default" size="100%">Article</style></work-type><urls><related-urls><url><style face="normal" font="default" size="100%">http://dx.doi.org/10.1038/nnano.2015.190</style></url></related-urls><pdf-urls><url>internal-pdf://naturenanotech_small-0583589376/naturenanotech_small.png</url></pdf-urls></urls><electronic-resource-num><style face="normal" font="default" size="100%">10.1038/nnano.2015.190</style></electronic-resource-num></record><record><database name="Alex2015.enl" path="\\ad.nfit.au.dk\NFDFS\Users\riber\Documents\Webpage\literature\Alex2015.enl">Alex2015.enl</database><source-app name="EndNote" version="16.0">EndNote</source-app><rec-number>15</rec-number><foreign-keys><key app="EN" db-id="2zevtz9fir00z3e95tbxsv92f25x99p2zrz2">15</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Riber, Camilla Frich</style></author><author><style face="normal" font="default" size="100%">Smith, Anton A. A.</style></author><author><style face="normal" font="default" size="100%">Zelikin, Alexander N.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Self-Immolative Linkers Literally Bridge Disulfide Chemistry and the Realm of Thiol-Free Drugs</style></title><secondary-title><style face="normal" font="default" size="100%">Advanced Healthcare Materials</style></secondary-title></titles><periodical><full-title><style face="normal" font="default" size="100%">Advanced Healthcare Materials</style></full-title></periodical><pages><style face="normal" font="default" size="100%">1887-1890</style></pages><volume><style face="normal" font="default" size="100%">4</style></volume><number><style face="normal" font="default" size="100%">12</style></number><keywords><keyword><style face="normal" font="default" size="100%">drug delivery</style></keyword><keyword><style face="normal" font="default" size="100%">disulfide reshuffling</style></keyword><keyword><style face="normal" font="default" size="100%">self immolative linkers</style></keyword><keyword><style face="normal" font="default" size="100%">macromolecular prodrugs</style></keyword></keywords><dates><year><style face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style face="normal" font="default" size="100%">32</style></date></pub-dates></dates><isbn><style face="normal" font="default" size="100%">2192-2659</style></isbn><urls><related-urls><url><style face="normal" font="default" size="100%">http://dx.doi.org/10.1002/adhm.201500344</style></url></related-urls><pdf-urls><url>internal-pdf://SILcommentary_small-2412305920/SILcommentary_small.png</url></pdf-urls></urls><electronic-resource-num><style face="normal" font="default" size="100%">10.1002/adhm.201500344</style></electronic-resource-num></record><record><database name="Alex2015.enl" path="\\ad.nfit.au.dk\NFDFS\Users\riber\Documents\Webpage\literature\Alex2015.enl">Alex2015.enl</database><source-app name="EndNote" version="16.0">EndNote</source-app><rec-number>10</rec-number><foreign-keys><key app="EN" db-id="2zevtz9fir00z3e95tbxsv92f25x99p2zrz2">10</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Jensen, Bettina E. B.</style></author><author><style face="normal" font="default" size="100%">Edlund, Katrine</style></author><author><style face="normal" font="default" size="100%">Zelikin, Alexander N.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Micro-structured, spontaneously eroding hydrogels accelerate endothelialization through presentation of conjugated growth factors</style></title><secondary-title><style face="normal" font="default" size="100%">Biomaterials</style></secondary-title></titles><periodical><full-title><style face="normal" font="default" size="100%">Biomaterials</style></full-title></periodical><pages><style face="normal" font="default" size="100%">113-124</style></pages><volume><style face="normal" font="default" size="100%">49</style></volume><number><style face="normal" font="default" size="100%">0</style></number><keywords><keyword><style face="normal" font="default" size="100%">Biomaterials</style></keyword><keyword><style face="normal" font="default" size="100%">Growth factors</style></keyword><keyword><style face="normal" font="default" size="100%">Hydrogels</style></keyword><keyword><style face="normal" font="default" size="100%">Bioconjugation</style></keyword></keywords><dates><year><style face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style face="normal" font="default" size="100%">31</style></date></pub-dates></dates><isbn><style face="normal" font="default" size="100%">0142-9612</style></isbn><abstract><style face="normal" font="default" size="100%">Growth factors represent highly potent and highly efficacious means of communication to cells. At the same time, these proteins are fragile and relatively small sized – rendering their immobilization and controlled release from biomaterials challenging. In this work, we establish a method to incorporate growth factors into the physical hydrogels based on poly(vinyl alcohol), PVA. The latter have a long and successful history of biomedical applications and approval for diverse use in human patients, but are also characterized with scant opportunities for bioconjugation and functionalization. Herein, we develop the conjugation of growth factors to the micro-structured, spontaneously eroding physical hydrogels based on PVA. Protein conjugation was elaborated using model substrates, albumin and lysozyme, which aided to reveal specificity of chemical reactions and benign, non-harmful nature of the established protocols. Surface-adhered format of hydrogel analyses allowed to quantify bioconjugation reactions and enzymatic activity of the immobilized proteins and to visualize the hydrogels with immobilized cargo. In cell culture, immobilized growth factors were effective in communicating to adhering cells and specifically enhanced proliferation rates of the cells containing the corresponding receptors. At the same time, proliferation of the cells devoid of these receptors was un-altered.</style></abstract><urls><related-urls><url><style face="normal" font="default" size="100%">http://www.sciencedirect.com/science/article/pii/S0142961215000538</style></url></related-urls><pdf-urls><url>internal-pdf://Microstructured_spontan_small-2574730496/Microstructured_spontan_small.png</url></pdf-urls></urls><electronic-resource-num><style face="normal" font="default" size="100%">10.1016/j.biomaterials.2015.01.036</style></electronic-resource-num></record><record><database name="Alex2015.enl" path="\\ad.nfit.au.dk\NFDFS\Users\riber\Documents\Webpage\literature\Alex2015.enl">Alex2015.enl</database><source-app name="EndNote" version="16.0">EndNote</source-app><rec-number>11</rec-number><foreign-keys><key app="EN" db-id="2zevtz9fir00z3e95tbxsv92f25x99p2zrz2">11</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Smith, Anton A. A.</style></author><author><style face="normal" font="default" size="100%">Zuwala, Kaja</style></author><author><style face="normal" font="default" size="100%">Kryger, Mille B. L.</style></author><author><style face="normal" font="default" size="100%">Wohl, Benjamin M.</style></author><author><style face="normal" font="default" size="100%">Guerrero-Sanchez, Carlos</style></author><author><style face="normal" font="default" size="100%">Tolstrup, Martin</style></author><author><style face="normal" font="default" size="100%">Postma, Almar</style></author><author><style face="normal" font="default" size="100%">Zelikin, Alexander N.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Macromolecular prodrugs of ribavirin: towards a treatment for co-infection with HIV and HCV</style></title><secondary-title><style face="normal" font="default" size="100%">Chemical Science</style></secondary-title></titles><periodical><full-title><style face="normal" font="default" size="100%">Chemical Science</style></full-title></periodical><pages><style face="normal" font="default" size="100%">264-269</style></pages><volume><style face="normal" font="default" size="100%">6</style></volume><number><style face="normal" font="default" size="100%">1</style></number><dates><year><style face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style face="normal" font="default" size="100%">28</style></date></pub-dates></dates><publisher><style face="normal" font="default" size="100%">The Royal Society of Chemistry</style></publisher><isbn><style face="normal" font="default" size="100%">2041-6520</style></isbn><abstract><style face="normal" font="default" size="100%">Human immunodeficiency virus (HIV) and hepatitis C virus (HCV) represent tremendous healthcare burdens with a large proportion of patients hosting the two viruses at the same time. An altered hepatic function and immunity as well as cross-interference of drugs make treatment of co-infection increasingly challenging. Herein we report the first design of macromolecular prodrugs (MP) with concurrent success in fighting HIV and alleviating hepatitis (liver inflammation). To achieve this, polymer compositions were systematically screened in a broad range of molar mass and content of ribavirin - a broad spectrum antiviral agent. For the first time, we report that ribavirin is efficacious in fighting HIV and in the form of MP, the treatment is safe, both in terms of lack of association of ribavirin with red blood cells and lack of toxicity upon cellular internalization. The lead polymer compositions were also potent in anti-inflammatory assays with relevance to viral hepatitis - thus making up formulations with potential for treatment of co-infection with HIV and HCV.</style></abstract><work-type><style face="normal" font="default" size="100%">10.1039/C4SC02754J</style></work-type><urls><related-urls><url><style face="normal" font="default" size="100%">http://dx.doi.org/10.1039/C4SC02754J</style></url></related-urls><pdf-urls><url>internal-pdf://cotreatment-HIV-HCV-small-1953926912/cotreatment-HIV-HCV-small.png</url></pdf-urls></urls><electronic-resource-num><style face="normal" font="default" size="100%">10.1039/C4SC02754J</style></electronic-resource-num></record><record><database name="Alex2015.enl" path="\\ad.nfit.au.dk\NFDFS\Users\riber\Documents\Webpage\literature\Alex2015.enl">Alex2015.enl</database><source-app name="EndNote" version="16.0">EndNote</source-app><rec-number>12</rec-number><foreign-keys><key app="EN" db-id="2zevtz9fir00z3e95tbxsv92f25x99p2zrz2">12</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ruiz-Sanchis, Pau</style></author><author><style face="normal" font="default" size="100%">Wohl, Benjamin M.</style></author><author><style face="normal" font="default" size="100%">Smith, Anton A. A.</style></author><author><style face="normal" font="default" size="100%">Zuwala, Kaja</style></author><author><style face="normal" font="default" size="100%">Melchjorsen, Jesper</style></author><author><style face="normal" font="default" size="100%">Tolstrup, Martin</style></author><author><style face="normal" font="default" size="100%">Zelikin, Alexander N.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Highly Active Macromolecular Prodrugs Inhibit Expression of the Hepatitis C Virus Genome in the Host Cells</style></title><secondary-title><style face="normal" font="default" size="100%">Advanced Healthcare Materials</style></secondary-title></titles><periodical><full-title><style face="normal" font="default" size="100%">Advanced Healthcare Materials</style></full-title></periodical><pages><style face="normal" font="default" size="100%">65-68</style></pages><volume><style face="normal" font="default" size="100%">4</style></volume><number><style face="normal" font="default" size="100%">1</style></number><keywords><keyword><style face="normal" font="default" size="100%">polymers</style></keyword><keyword><style face="normal" font="default" size="100%">prodrugs</style></keyword><keyword><style face="normal" font="default" size="100%">drug delivery</style></keyword><keyword><style face="normal" font="default" size="100%">hepatitis C virus</style></keyword></keywords><dates><year><style face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style face="normal" font="default" size="100%">27</style></date></pub-dates></dates><isbn><style face="normal" font="default" size="100%">2192-2659</style></isbn><urls><related-urls><url><style face="normal" font="default" size="100%">http://dx.doi.org/10.1002/adhm.201400307</style></url></related-urls><pdf-urls><url>internal-pdf://highly-active-macromolecular-prodrugs-small-3530985216/highly-active-macromolecular-prodrugs-small.png</url></pdf-urls></urls><electronic-resource-num><style face="normal" font="default" size="100%">10.1002/adhm.201400307</style></electronic-resource-num></record><record><database name="Alex2015.enl" path="\\ad.nfit.au.dk\NFDFS\Users\riber\Documents\Webpage\literature\Alex2015.enl">Alex2015.enl</database><source-app name="EndNote" version="16.0">EndNote</source-app><rec-number>13</rec-number><foreign-keys><key app="EN" db-id="2zevtz9fir00z3e95tbxsv92f25x99p2zrz2">13</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Zuwala, Kaja</style></author><author><style face="normal" font="default" size="100%">Smith, Anton A. A.</style></author><author><style face="normal" font="default" size="100%">Postma, Almar</style></author><author><style face="normal" font="default" size="100%">Guerrero-Sanchez, Carlos</style></author><author><style face="normal" font="default" size="100%">Ruiz-Sanchis, Pau</style></author><author><style face="normal" font="default" size="100%">Melchjorsen, Jesper</style></author><author><style face="normal" font="default" size="100%">Tolstrup, Martin</style></author><author><style face="normal" font="default" size="100%">Zelikin, Alexander N.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Polymers Fight HIV: Potent (Pro)Drugs Identified Through Parallel Automated Synthesis</style></title><secondary-title><style face="normal" font="default" size="100%">Advanced Healthcare Materials</style></secondary-title></titles><periodical><full-title><style face="normal" font="default" size="100%">Advanced Healthcare Materials</style></full-title></periodical><pages><style face="normal" font="default" size="100%">46-50</style></pages><volume><style face="normal" font="default" size="100%">4</style></volume><number><style face="normal" font="default" size="100%">1</style></number><keywords><keyword><style face="normal" font="default" size="100%">polymers</style></keyword><keyword><style face="normal" font="default" size="100%">prodrugs</style></keyword><keyword><style face="normal" font="default" size="100%">drug delivery</style></keyword><keyword><style face="normal" font="default" size="100%">HIV</style></keyword></keywords><dates><year><style face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style face="normal" font="default" size="100%">24</style></date></pub-dates></dates><isbn><style face="normal" font="default" size="100%">2192-2659</style></isbn><urls><related-urls><url><style face="normal" font="default" size="100%">http://dx.doi.org/10.1002/adhm.201400148</style></url></related-urls><pdf-urls><url>internal-pdf://HIV-macromolecular-prodrugs-small-0544641024/HIV-macromolecular-prodrugs-small.png</url></pdf-urls></urls><electronic-resource-num><style face="normal" font="default" size="100%">10.1002/adhm.201400148</style></electronic-resource-num></record></records></xml>