<?xml version="1.0" encoding="UTF-8" ?><xml><records><record><database name="Alex2012.enl" path="E:\Dropbox\MPCL Website\literature\Alex2012.enl">Alex2012.enl</database><source-app name="EndNote" version="16.0">EndNote</source-app><rec-number>9</rec-number><foreign-keys><key app="EN" db-id="0rfext9920xf92epx2qxww5f0t2arrw9wpwf">9</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Fejerskov, Betina</style></author><author><style face="normal" font="default" size="100%">Zelikin, Alexander N.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Substrate Mediated Enzyme Prodrug Therapy</style></title><secondary-title><style face="normal" font="default" size="100%">PLoS ONE</style></secondary-title></titles><periodical><full-title><style face="normal" font="default" size="100%">PLoS ONE</style></full-title></periodical><pages><style face="normal" font="default" size="100%">e49619</style></pages><volume><style face="normal" font="default" size="100%">7</style></volume><number><style face="normal" font="default" size="100%">11</style></number><dates><year><style face="normal" font="default" size="100%">2012</style></year><pub-dates><date><style face="normal" font="default" size="100%">13</style></date></pub-dates></dates><publisher><style face="normal" font="default" size="100%">Public Library of Science</style></publisher><abstract><style face="normal" font="default" size="100%">&lt;p&gt;In this report, we detail Substrate Mediated Enzyme Prodrug Therapy (SMEPT) as a novel approach in drug delivery which relies on enzyme-functionalized cell culture substrates to achieve a localized conversion of benign prodrug(s) into active therapeutics with subsequent delivery to adhering cells or adjacent tissues. For proof-of-concept SMEPT, we use surface adhered micro-structured physical hydrogels based on poly(vinyl alcohol), β-glucuronidase enzyme and glucuronide prodrugs. We demonstrate enzymatic activity mediated by the assembled hydrogel samples and illustrate arms of control over rate of release of model fluorescent cargo. SMEPT was not impaired by adhering cells and afforded facile time - and dose – dependent uptake of the in situ generated fluorescent cargo by hepatic cells, HepG2. With the use of a glucuronide derivative of an anticancer drug, SN-38, SMEPT afforded a decrease in cell viability to a level similar to that achieved using parent drug. Finally, dose response was achieved using SMEPT and administration of judiciously chosen concentration of SN-38 glucuronide prodrug thus revealing external control over drug delivery using drug eluting surface. We believe that this highly adaptable concept will find use in diverse biomedical applications, specifically surface mediated drug delivery and tissue engineering.&lt;/p&gt;</style></abstract><urls><related-urls><url><style face="normal" font="default" size="100%">http://dx.doi.org/10.1371%2Fjournal.pone.0049619</style></url></related-urls><pdf-urls><url>internal-pdf://SMEPT-2_small-0073727489/SMEPT-2_small.png</url></pdf-urls></urls><electronic-resource-num><style face="normal" font="default" size="100%">10.1371/journal.pone.0049619</style></electronic-resource-num></record><record><database name="Alex2012.enl" path="E:\Dropbox\MPCL Website\literature\Alex2012.enl">Alex2012.enl</database><source-app name="EndNote" version="16.0">EndNote</source-app><rec-number>5</rec-number><foreign-keys><key app="EN" db-id="0rfext9920xf92epx2qxww5f0t2arrw9wpwf">5</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Hosta-Rigau, Leticia</style></author><author><style face="normal" font="default" size="100%">Jensen, Bettina E. B.</style></author><author><style face="normal" font="default" size="100%">Fjeldsø, Kit S.</style></author><author><style face="normal" font="default" size="100%">Postma, Almar</style></author><author><style face="normal" font="default" size="100%">Li, Guoxin</style></author><author><style face="normal" font="default" size="100%">Goldie, Kenneth N.</style></author><author><style face="normal" font="default" size="100%">Albericio, Fernando</style></author><author><style face="normal" font="default" size="100%">Zelikin, Alexander N.</style></author><author><style face="normal" font="default" size="100%">Städler, Brigitte</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Surface-Adhered Composite Poly(Vinyl Alcohol) Physical Hydrogels: Polymersome-Aided Delivery of Therapeutic Small Molecules</style></title><secondary-title><style face="normal" font="default" size="100%">Advanced Healthcare Materials</style></secondary-title></titles><periodical><full-title><style face="normal" font="default" size="100%">Advanced Healthcare Materials</style></full-title></periodical><pages><style face="normal" font="default" size="100%">n/a-n/a</style></pages><keywords><keyword><style face="normal" font="default" size="100%">polymersomes</style></keyword><keyword><style face="normal" font="default" size="100%">surface-mediated drug delivery</style></keyword><keyword><style face="normal" font="default" size="100%">PVA hydrogels</style></keyword><keyword><style face="normal" font="default" size="100%">myoblast cell viability</style></keyword><keyword><style face="normal" font="default" size="100%">gold nanoparticles</style></keyword></keywords><dates><year><style face="normal" font="default" size="100%">2012</style></year><pub-dates><date><style face="normal" font="default" size="100%">12</style></date></pub-dates></dates><publisher><style face="normal" font="default" size="100%">WILEY-VCH Verlag</style></publisher><isbn><style face="normal" font="default" size="100%">2192-2659</style></isbn><urls><related-urls><url><style face="normal" font="default" size="100%">http://dx.doi.org/10.1002/adhm.201200092</style></url></related-urls><pdf-urls><url>internal-pdf://Composite_hydrogels-3704479002/Composite_hydrogels.png</url></pdf-urls></urls><electronic-resource-num><style face="normal" font="default" size="100%">10.1002/adhm.201200092</style></electronic-resource-num></record><record><database name="Alex2012.enl" path="E:\Dropbox\MPCL Website\literature\Alex2012.enl">Alex2012.enl</database><source-app name="EndNote" version="16.0">EndNote</source-app><rec-number>6</rec-number><foreign-keys><key app="EN" db-id="0rfext9920xf92epx2qxww5f0t2arrw9wpwf">6</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Hinton, T. M.</style></author><author><style face="normal" font="default" size="100%">Monaghan, P.</style></author><author><style face="normal" font="default" size="100%">Green, D.</style></author><author><style face="normal" font="default" size="100%">Kooijmans, S. A. A.</style></author><author><style face="normal" font="default" size="100%">Shi, S.</style></author><author><style face="normal" font="default" size="100%">Breheney, K.</style></author><author><style face="normal" font="default" size="100%">Tizard, M.</style></author><author><style face="normal" font="default" size="100%">Nicolazzo, J. A.</style></author><author><style face="normal" font="default" size="100%">Zelikin, A. N.</style></author><author><style face="normal" font="default" size="100%">Wark, K.</style></author></authors></contributors><auth-address><style face="normal" font="default" size="100%">CSIRO Livestock Industries, Australian Animal Health Laboratory, 5 Portarlington Road, East Geelong, VIC 3219, Australia&#xD;Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, VIC 3052, Australia&#xD;CSIRO Materials Science and Engineering, 343 Royal Parade, Parkville, VIC 3220, Australia&#xD;Department of Chemistry, INANO Interdisciplinary Nanoscience Centre, Aarhus University, Denmark&#xD;Victorian Cancer Agency, 12 Victoria Street, Carlton, VIC 3053, Australia</style></auth-address><titles><title><style face="normal" font="default" size="100%">Biodistribution of polymer hydrogel capsules for the delivery of therapeutics</style></title><secondary-title><style face="normal" font="default" size="100%">Acta Biomaterialia</style></secondary-title></titles><periodical><full-title><style face="normal" font="default" size="100%">Acta Biomaterialia</style></full-title></periodical><pages><style face="normal" font="default" size="100%">3251-3260</style></pages><volume><style face="normal" font="default" size="100%">8</style></volume><number><style face="normal" font="default" size="100%">9</style></number><keywords><keyword><style face="normal" font="default" size="100%">Confocal microscopy</style></keyword><keyword><style face="normal" font="default" size="100%">Hepatocyte</style></keyword><keyword><style face="normal" font="default" size="100%">Kupffer cell</style></keyword><keyword><style face="normal" font="default" size="100%">PMA HCs</style></keyword><keyword><style face="normal" font="default" size="100%">Therapeutics delivery</style></keyword><keyword><style face="normal" font="default" size="100%">CD163 antigen</style></keyword><keyword><style face="normal" font="default" size="100%">drug carrier</style></keyword><keyword><style face="normal" font="default" size="100%">polymer hydrogel capsule</style></keyword><keyword><style face="normal" font="default" size="100%">polymethacrylic acid</style></keyword><keyword><style face="normal" font="default" size="100%">unclassified drug</style></keyword><keyword><style face="normal" font="default" size="100%">animal cell</style></keyword><keyword><style face="normal" font="default" size="100%">animal experiment</style></keyword><keyword><style face="normal" font="default" size="100%">article</style></keyword><keyword><style face="normal" font="default" size="100%">cell culture</style></keyword><keyword><style face="normal" font="default" size="100%">cell line</style></keyword><keyword><style face="normal" font="default" size="100%">cell membrane</style></keyword><keyword><style face="normal" font="default" size="100%">cellular distribution</style></keyword><keyword><style face="normal" font="default" size="100%">electron microscopy</style></keyword><keyword><style face="normal" font="default" size="100%">endothelium cell</style></keyword><keyword><style face="normal" font="default" size="100%">flow cytometry</style></keyword><keyword><style face="normal" font="default" size="100%">heart</style></keyword><keyword><style face="normal" font="default" size="100%">hydrogel</style></keyword><keyword><style face="normal" font="default" size="100%">in vitro study</style></keyword><keyword><style face="normal" font="default" size="100%">in vivo study</style></keyword><keyword><style face="normal" font="default" size="100%">kidney</style></keyword><keyword><style face="normal" font="default" size="100%">liver</style></keyword><keyword><style face="normal" font="default" size="100%">liver cell</style></keyword><keyword><style face="normal" font="default" size="100%">lung</style></keyword><keyword><style face="normal" font="default" size="100%">lysosome</style></keyword><keyword><style face="normal" font="default" size="100%">mouse</style></keyword><keyword><style face="normal" font="default" size="100%">nonhuman</style></keyword><keyword><style face="normal" font="default" size="100%">priority journal</style></keyword><keyword><style face="normal" font="default" size="100%">rat</style></keyword><keyword><style face="normal" font="default" size="100%">spleen</style></keyword><keyword><style face="normal" font="default" size="100%">Alexa</style></keyword><keyword><style face="normal" font="default" size="100%">Rattus</style></keyword></keywords><dates><year><style face="normal" font="default" size="100%">2012</style></year><pub-dates><date><style face="normal" font="default" size="100%">11</style></date></pub-dates></dates><isbn><style face="normal" font="default" size="100%">17427061 (ISSN)</style></isbn><abstract><style face="normal" font="default" size="100%">A key phase in the development of intelligently designed nanoparticle delivery vehicles for new therapeutic agents is to gain an understanding of their interaction with tissues and cells. We report a series of in vitro and in vivo experiments aimed at tracking a potential delivery vehicle for therapeutic agents, including vaccine peptides and drugs derived from poly(methacrylic acid) hydrogel capsules in certain organs and cell types. For the in vitro studies, two immortal liver-derived cell lines (Huh7 and Hepa1-6) and primary cultures of mouse hepatocytes were incubated with Alexa 647 labelled fluorescent capsules to track their internalization and intracellular distribution by confocal microscopy. Capsules, 500 nm in diameter, were taken up into the cells in a time-dependent manner in all three cell lines. Capsules were observed in plasma membrane-derived vesicles within the cells. After 24 h a significant proportion of the capsules was observed in lysosomes. To understand the behaviour of the capsules in vivo, Alexa 488 labelled fluorescent capsules were intravenously injected into Sprague-Dawley rats and after 24 h the fate of the capsules in a number of organs was determined by flow cytometry and confocal microscopy. By flow cytometry, the majority of the capsules were detected in the spleen whilst similar numbers were found in the lung and liver. By confocal microscopy, the majority of the capsules were found in the liver and spleen with significantly less capsules in the lung, heart and kidney. Colocalization of capsules with cell-type specific markers indicated that in lung, heart and kidney, the majority of the capsules were located in endothelial cells. In the spleen ∼50% of the capsules were found in CD163-positive cells, whereas in the liver, almost all capsules were located in CD163-positive cells, indicating uptake by Kupffer cells. Electron microscopy confirmed the presence of capsules within Kupffer cells. © 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.</style></abstract><notes><style face="normal" font="default" size="100%">Export Date: 17 September 2012&#xD;Source: Scopus&#xD;Language of Original Document: English&#xD;Correspondence Address: Hinton, T.M.; CSIRO Livestock Industries, Australian Animal Health Laboratory, 5 Portarlington Road, East Geelong, VIC 3219, Australia; email: Tracey.Hinton@csiro.au&#xD;Chemicals/CAS: polymethacrylic acid, 25087-26-7&#xD;References: Lares, M.R., Rossi, J.J., Ouellet, D.L., RNAi and small interfering RNAs in human disease therapeutic applications (2010) Trends Biotechnol, 28 (11), pp. 570-579; Vasey, P.A., Kaye, S.B., Morrison, R., Twelves, C., Wilson, P., Duncan, R., Thomson, A.H., Cassidy, J., Phase I clinical and pharmacokinetic study of PK1 [N-(2- hydroxypropyl)methacrylamide copolymer doxorubicin]: First member of a new class of chemotherapeutic agents - Drug-polymer conjugates (1999) Clinical Cancer Research, 5 (1), pp. 83-94; Hashizume, H., Baluk, P., Morikawa, S., McLean, J.W., Thurston, G., Roberge, S., Jain, R.K., McDonald, D.M., Openings between defective endothelial cells explain tumor vessel leakiness (2000) American Journal of Pathology, 156 (4), pp. 1363-1380; 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B.</style></author><author><style face="normal" font="default" size="100%">Jensen, Najah B. S.</style></author><author><style face="normal" font="default" size="100%">Chong, Siow-Feng</style></author><author><style face="normal" font="default" size="100%">Zelikin, Alexander N.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Engineering Surface Adhered Poly(vinyl alcohol) Physical Hydrogels as Enzymatic Microreactors</style></title><secondary-title><style face="normal" font="default" size="100%">ACS Applied Materials &amp; Interfaces</style></secondary-title></titles><periodical><full-title><style face="normal" font="default" size="100%">ACS Applied Materials &amp; Interfaces</style></full-title></periodical><pages><style face="normal" font="default" size="100%">4981–4990</style></pages><volume><style face="normal" font="default" size="100%">4</style></volume><number><style face="normal" font="default" size="100%">9</style></number><dates><year><style face="normal" font="default" size="100%">2012</style></year><pub-dates><date><style face="normal" font="default" size="100%">10</style></date></pub-dates></dates><publisher><style face="normal" font="default" size="100%">American Chemical Society</style></publisher><isbn><style face="normal" font="default" size="100%">1944-8244</style></isbn><abstract><style face="normal" font="default" size="100%">In this work, we characterize physical hydrogels based on poly(vinyl alcohol), PVA, as intelligent biointerfaces for surface-mediated drug delivery. Specifically, we assemble microstructured (?S) surface adhered hydrogels via noncryogenic gelation of PVA, namely polymer coagulation using sodium sulfate (Na2SO4). We present systematic investigation of concentrations of Na2SO4 as a tool of control over assembly of ?S PVA hydrogels and quantify polymer losses and retention within the hydrogels. For polymer quantification, we use custom-made PVA with single terminal thiol group in a form of mixed disulfide with Ellman?s reagent which provides for a facile UV?vis assay of polymer content in coagulation baths, subsequent washes in physiological buffer, and within the hydrogel phase. Polymer coagulation using varied concentrations of sodium sulfate afforded biointerfaces with controlled elasticity for potential uses in investigating mechano-sensitive effects of mammalian cell culture. For surface mediated drug delivery, we propose a novel concept termed Substrate Mediated Enzyme Prodrug Therapy (SMEPT) and characterize ?S PVA hydrogels as reservoirs for enzymatic cargo. Assembled functional interfaces are used as matrices for cell culture and delivery of anticancer drug achieved through administration of a benign prodrug, its conversion into an active therapeutic within the hydrogel phase, and subsequent internalization by adhered hepatic cells. Taken together, the presented data contribute significantly to the development of novel matrices for surface-mediated drug delivery and other biomedical applications.</style></abstract><urls><related-urls><url><style face="normal" font="default" size="100%">http://dx.doi.org/10.1021/am3013467</style></url></related-urls><pdf-urls><url>internal-pdf://SMEPT1-2713432858/SMEPT1.png</url></pdf-urls></urls><electronic-resource-num><style face="normal" font="default" size="100%">10.1021/am3013467</style></electronic-resource-num><access-date><style face="normal" font="default" size="100%">2012/09/17</style></access-date></record><record><database name="Alex2012.enl" path="E:\Dropbox\MPCL Website\literature\Alex2012.enl">Alex2012.enl</database><source-app name="EndNote" version="16.0">EndNote</source-app><rec-number>2</rec-number><foreign-keys><key app="EN" db-id="0rfext9920xf92epx2qxww5f0t2arrw9wpwf">2</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Jensen, B. E. B.</style></author><author><style face="normal" font="default" size="100%">Alves, M. H.</style></author><author><style face="normal" font="default" size="100%">Fejerskov, B.</style></author><author><style face="normal" font="default" size="100%">Städler, B.</style></author><author><style face="normal" font="default" size="100%">Zelikin, A. N.</style></author></authors></contributors><auth-address><style face="normal" font="default" size="100%">Department of Chemistry, Aarhus University, Aarhus, Denmark&#xD;INano Interdisciplinary Nanoscience Centre, Aarhus University, Aarhus, Denmark</style></auth-address><titles><title><style face="normal" font="default" size="100%">Surface adhered poly(vinyl alcohol) physical hydrogels as tools for rational design of intelligent biointerfaces</style></title><secondary-title><style face="normal" font="default" size="100%">Soft Matter</style></secondary-title></titles><periodical><full-title><style face="normal" font="default" size="100%">Soft Matter</style></full-title></periodical><pages><style face="normal" font="default" size="100%">4625-4634</style></pages><volume><style face="normal" font="default" size="100%">8</style></volume><number><style face="normal" font="default" size="100%">17</style></number><keywords><keyword><style face="normal" font="default" size="100%">Amine groups</style></keyword><keyword><style face="normal" font="default" size="100%">Biointerfaces</style></keyword><keyword><style face="normal" font="default" size="100%">Effective tool</style></keyword><keyword><style face="normal" font="default" size="100%">Fluorescent probes</style></keyword><keyword><style face="normal" font="default" size="100%">Hydrogelation</style></keyword><keyword><style face="normal" font="default" size="100%">Iso-propanols</style></keyword><keyword><style face="normal" font="default" size="100%">Low molecular weight</style></keyword><keyword><style face="normal" font="default" size="100%">Model proteins</style></keyword><keyword><style face="normal" font="default" size="100%">Physiological buffers</style></keyword><keyword><style face="normal" font="default" size="100%">Physiological condition</style></keyword><keyword><style face="normal" font="default" size="100%">Polymer molecular weight</style></keyword><keyword><style face="normal" font="default" size="100%">PVA films</style></keyword><keyword><style face="normal" font="default" size="100%">PVA-gel</style></keyword><keyword><style face="normal" font="default" size="100%">Rational design</style></keyword><keyword><style face="normal" font="default" size="100%">Stabilization methods</style></keyword><keyword><style face="normal" font="default" size="100%">Young&apos;s Modulus</style></keyword><keyword><style face="normal" font="default" size="100%">Cell adhesion</style></keyword><keyword><style face="normal" font="default" size="100%">Coagulation</style></keyword><keyword><style face="normal" font="default" size="100%">Design</style></keyword><keyword><style face="normal" font="default" size="100%">Drug delivery</style></keyword><keyword><style face="normal" font="default" size="100%">Gelation</style></keyword><keyword><style face="normal" font="default" size="100%">Molecular weight</style></keyword><keyword><style face="normal" font="default" size="100%">Physiological models</style></keyword><keyword><style face="normal" font="default" size="100%">Physiology</style></keyword><keyword><style face="normal" font="default" size="100%">Polyethylene glycols</style></keyword><keyword><style face="normal" font="default" size="100%">Polymer films</style></keyword><keyword><style face="normal" font="default" size="100%">Polymers</style></keyword><keyword><style face="normal" font="default" size="100%">Stabilization</style></keyword><keyword><style face="normal" font="default" size="100%">Surfaces</style></keyword><keyword><style face="normal" font="default" size="100%">Tissue engineering</style></keyword><keyword><style face="normal" font="default" size="100%">Hydrogels</style></keyword></keywords><dates><year><style face="normal" font="default" size="100%">2012</style></year><pub-dates><date><style face="normal" font="default" size="100%">9</style></date></pub-dates></dates><isbn><style face="normal" font="default" size="100%">1744683X (ISSN)</style></isbn><abstract><style face="normal" font="default" size="100%">We develop three independent non-cryogenic techniques for the production of physical hydrogels based on poly(vinyl alcohol), PVA, as surface adhered materials. Hydrogelation of the micro-structured PVA films was achieved using a coagulating salt (sodium sulfate), aqueous isopropanol, and poly(ethylene glycol), and each of the methods afforded robust hydrogels which remained stable under physiological conditions for at least 48 h. The choice of the stabilization method and polymer molecular weight was decisive in controlling hydrogel dimensions (swelling) and Young&apos;s modulus, the latter varied from 20 to 2000 kPa. Immobilization and retention of model low molecular weight cargo were monitored using a custom-made PVA with terminal amine groups, conjugating a fluorescent probe to this polymer and co-gelation of the conjugate with matrix forming PVA. Polymer losses during stabilization and kinetics of cargo release in PBS over time differed depending on the hydrogel stabilization method employed making the latter an effective tool in the design of intelligent biointerfaces. For each stabilization method, we demonstrate retention of model protein cargo over at least 48 h of incubation in physiological buffer, a phenomenon which was used to render the non-adhesive pristine PVA gels well suited for cell adhesion and proliferation. Taken together, we present a flexible and highly adaptable platform for the design of intelligent biointerfaces towards their use in tissue engineering and surface mediated drug delivery. © 2012 The Royal Society of Chemistry.</style></abstract><notes><style face="normal" font="default" size="100%">Export Date: 12 July 2012&#xD;Source: Scopus&#xD;CODEN: SMOAB&#xD;Language of Original Document: English&#xD;Correspondence Address: Zelikin, A.N.; Department of Chemistry, Aarhus University, Aarhus, Denmark; email: zelikin@chem.au.dk&#xD;References: Hassan, C.M., Peppas, N.A., (2000) Adv. Polym. Sci., 153, pp. 37-65; Slaughter, B.V., Khurshid, S.S., Fisher, O.Z., Khademhosseini, A., Peppas, N.A., (2009) Adv. 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Res., 57, pp. 217-223; Chuang, W.Y., Young, T.H., Yao, C.H., Chiu, W.Y., (1999) Biomaterials, 20, pp. 1479-1487</style></notes><urls><related-urls><url><style face="normal" font="default" size="100%">http://www.scopus.com/inward/record.url?eid=2-s2.0-84859762582&amp;partnerID=40&amp;md5=2b66959f3eb51622d096d2d571ea7678</style></url></related-urls><pdf-urls><url>internal-pdf://softmatter-3770397466/softmatter.png</url></pdf-urls></urls><electronic-resource-num><style face="normal" font="default" size="100%">10.1039/c2sm07075h</style></electronic-resource-num></record><record><database name="Alex2012.enl" path="E:\Dropbox\MPCL Website\literature\Alex2012.enl">Alex2012.enl</database><source-app name="EndNote" version="16.0">EndNote</source-app><rec-number>3</rec-number><foreign-keys><key app="EN" db-id="0rfext9920xf92epx2qxww5f0t2arrw9wpwf">3</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Zelikin, Alexander N.</style></author><author><style face="normal" font="default" size="100%">Städler, Brigitte</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Intelligent Polymer Thin Films and Coatings for Drug Delivery</style></title><secondary-title><style face="normal" font="default" size="100%">Book chapter in “Intelligent Surfaces in Biotechnology: Scientific and Engineering Concepts, Enabling Technologies, and Translation to Bio-Oriented Applications”</style></secondary-title></titles><periodical><full-title><style face="normal" font="default" size="100%">Book chapter in “Intelligent Surfaces in Biotechnology: Scientific and Engineering Concepts, Enabling Technologies, and Translation to Bio-Oriented Applications”</style></full-title></periodical><pages><style face="normal" font="default" size="100%">243-290</style></pages><keywords><keyword><style face="normal" font="default" size="100%">sequential polymer deposition</style></keyword><keyword><style face="normal" font="default" size="100%">intelligent polymer coatings</style></keyword><keyword><style face="normal" font="default" size="100%">bioconjugation of CD</style></keyword><keyword><style face="normal" font="default" size="100%">poly(β-aminoesters) choice</style></keyword><keyword><style face="normal" font="default" size="100%">multilayered polymer films</style></keyword></keywords><dates><year><style face="normal" font="default" size="100%">2012</style></year><pub-dates><date><style face="normal" font="default" size="100%">8</style></date></pub-dates></dates><publisher><style face="normal" font="default" size="100%">John Wiley &amp; Sons, Inc.</style></publisher><isbn><style face="normal" font="default" size="100%">9781118181249</style></isbn><abstract><style face="normal" font="default" size="100%">This chapter contains sections titled: * Introduction * Surface-Mediated Drug Delivery * Drug Delivery Vehicles with Functional Polymer Coatings * Concluding Remarks * References</style></abstract><urls><related-urls><url><style face="normal" font="default" size="100%">http://dx.doi.org/10.1002/9781118181249.ch7</style></url></related-urls><pdf-urls><url>internal-pdf://book chapter-0767277338/book chapter.png</url></pdf-urls></urls><electronic-resource-num><style face="normal" font="default" size="100%">10.1002/9781118181249.ch7</style></electronic-resource-num></record><record><database name="Alex2012.enl" path="E:\Dropbox\MPCL Website\literature\Alex2012.enl">Alex2012.enl</database><source-app name="EndNote" version="16.0">EndNote</source-app><rec-number>4</rec-number><foreign-keys><key app="EN" db-id="0rfext9920xf92epx2qxww5f0t2arrw9wpwf">4</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Smith, A. A. A.</style></author><author><style face="normal" font="default" size="100%">Hussmann, T.</style></author><author><style face="normal" font="default" size="100%">Elich, J.</style></author><author><style face="normal" font="default" size="100%">Postma, A.</style></author><author><style face="normal" font="default" size="100%">Alves, M. H.</style></author><author><style face="normal" font="default" size="100%">Zelikin, A. N.</style></author></authors></contributors><auth-address><style face="normal" font="default" size="100%">Department of Chemistry, Aarhus University, Aarhus C 8000, Denmark&#xD;CSIRO - Materials Science and Engineering, Clayton, VIC, Australia</style></auth-address><titles><title><style face="normal" font="default" size="100%">Macromolecular design of poly(vinyl alcohol) by RAFT polymerization</style></title><secondary-title><style face="normal" font="default" size="100%">Polymer Chemistry</style></secondary-title></titles><periodical><full-title><style face="normal" font="default" size="100%">Polymer Chemistry</style></full-title></periodical><pages><style face="normal" font="default" size="100%">85-88</style></pages><volume><style face="normal" font="default" size="100%">3</style></volume><number><style face="normal" font="default" size="100%">1</style></number><keywords><keyword><style face="normal" font="default" size="100%">Amine groups</style></keyword><keyword><style face="normal" font="default" size="100%">Bio-conjugation</style></keyword><keyword><style face="normal" font="default" size="100%">Controlled molecular weight</style></keyword><keyword><style face="normal" font="default" size="100%">Flexible tool</style></keyword><keyword><style face="normal" font="default" size="100%">Macromolecular design</style></keyword><keyword><style face="normal" font="default" size="100%">Materials design</style></keyword><keyword><style face="normal" font="default" size="100%">RAft polymerization</style></keyword><keyword><style face="normal" font="default" size="100%">Reversible addition-fragmentation chain transfer polymerization</style></keyword><keyword><style face="normal" font="default" size="100%">Syndiotactic chains</style></keyword><keyword><style face="normal" font="default" size="100%">Syndiotactics</style></keyword><keyword><style face="normal" font="default" size="100%">Chemistry</style></keyword><keyword><style face="normal" font="default" size="100%">Polymers</style></keyword><keyword><style face="normal" font="default" size="100%">Living polymerization</style></keyword></keywords><dates><year><style face="normal" font="default" size="100%">2012</style></year><pub-dates><date><style face="normal" font="default" size="100%">7</style></date></pub-dates></dates><isbn><style face="normal" font="default" size="100%">17599954 (ISSN)</style></isbn><abstract><style face="normal" font="default" size="100%">Reversible Addition-Fragmentation chain Transfer polymerization (RAFT) is employed herein to obtain the first example of poly(vinyl alcohol), PVA, with controlled molecular weight and terminal amine groups thus presenting a flexible tool for materials design and bioconjugation. Furthermore, we demonstrate that RAFT control can be used to facilitate syndiotactic chain propagation and obtain PVA with the highest reported content of syndiotactic dyad (∼78%).</style></abstract><notes><style face="normal" font="default" size="100%">Cited By (since 1996): 1&#xD;Export Date: 12 July 2012&#xD;Source: Scopus&#xD;Language of Original Document: English&#xD;Correspondence Address: Zelikin, A.N.; Department of Chemistry, Aarhus University, Aarhus C 8000, Denmark; email: zelikin@chem.au.dk&#xD;References: Liechty, W.B., Kryscio, D.R., Slaughter, B.V., Peppas, N.A., (2010) Annu. Rev. Chem. Biomol. Eng., 1, p. 149; Duncan, R., (2003) Nat. Rev. Drug Discovery, 2, p. 347; Demerlis, C.C., Schoneker, D.R., (2003) Food Chem. Toxicol., 41, p. 319; Tadavarthy, S.M., Moller, J.H., Amplatz, K., (1975) Am. J. Roentgenol., Radium Ther. Nucl. Med., 125, p. 609; Davidson, G.S., Terbrugge, K.G., (1995) Am. J. Neuroradiol., 16, p. 843; Yamaoka, T., Tabata, Y., Ikada, Y., (1995) J. Pharm. 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