<?xml version="1.0" encoding="UTF-8" ?><xml><records><record><database name="Alex2018.enl" path="C:\Users\au302135\Dropbox (Depcon)\MPCL Website\literature\Alex2018.enl">Alex2018.enl</database><source-app name="EndNote" version="18.2">EndNote</source-app><rec-number>2</rec-number><foreign-keys><key app="EN" db-id="s5wdvv2szdtxxfer0t3pzdxoxewd5t9appdt">2</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Andersen, Anna H. F.</style></author><author><style face="normal" font="default" size="100%">Riber, Camilla F.</style></author><author><style face="normal" font="default" size="100%">Zuwala, Kaja</style></author><author><style face="normal" font="default" size="100%">Tolstrup, Martin</style></author><author><style face="normal" font="default" size="100%">Dagnæs-Hansen, Frederik</style></author><author><style face="normal" font="default" size="100%">Denton, Paul W.</style></author><author><style face="normal" font="default" size="100%">Zelikin, Alexander N.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Long-Acting, Potent Delivery of Combination Antiretroviral Therapy</style></title><secondary-title><style face="normal" font="default" size="100%">ACS Macro Letters</style></secondary-title></titles><periodical><full-title><style face="normal" font="default" size="100%">ACS Macro Letters</style></full-title></periodical><pages><style face="normal" font="default" size="100%">587-591</style></pages><volume><style face="normal" font="default" size="100%">7</style></volume><number><style face="normal" font="default" size="100%">5</style></number><dates><year><style face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style face="normal" font="default" size="100%">2018/05/15</style></date></pub-dates></dates><publisher><style face="normal" font="default" size="100%">American Chemical Society</style></publisher><urls><related-urls><url><style face="normal" font="default" size="100%">https://doi.org/10.1021/acsmacrolett.8b00179</style></url></related-urls></urls><electronic-resource-num><style face="normal" font="default" size="100%">10.1021/acsmacrolett.8b00179</style></electronic-resource-num></record><record><database name="Alex2018.enl" path="C:\Users\au302135\Dropbox (Depcon)\MPCL Website\literature\Alex2018.enl">Alex2018.enl</database><source-app name="EndNote" version="18.2">EndNote</source-app><rec-number>1</rec-number><foreign-keys><key app="EN" db-id="s5wdvv2szdtxxfer0t3pzdxoxewd5t9appdt">1</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Olesen, Morten T. Jarlstad</style></author><author><style face="normal" font="default" size="100%">Winther, Anna K.</style></author><author><style face="normal" font="default" size="100%">Fejerskov, Betina</style></author><author><style face="normal" font="default" size="100%">Dagnaes-Hansen, Frederik</style></author><author><style face="normal" font="default" size="100%">Simonsen, Ulf</style></author><author><style face="normal" font="default" size="100%">Zelikin, Alexander N.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Bi-Enzymatic Embolization Beads for Two-Armed Enzyme-Prodrug Therapy</style></title><secondary-title><style face="normal" font="default" size="100%">ADVANCED THERAPEUTICS</style></secondary-title></titles><periodical><full-title><style face="normal" font="default" size="100%">ADVANCED THERAPEUTICS</style></full-title></periodical><pages><style face="normal" font="default" size="100%">1800023</style></pages><volume><style face="normal" font="default" size="100%">0</style></volume><number><style face="normal" font="default" size="100%">0</style></number><dates><year><style face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style face="normal" font="default" size="100%">2018/06/05/</style></date></pub-dates></dates><abstract><style face="normal" font="default" size="100%">Abstract Embolic beads, a successful tool for localized, site-specific drug delivery, are engineered herein to contain the toolbox of enzyme-prodrug therapy (EPT). EPT offers facile means to synthesize diverse drugs at their nominated concentrations; individually, in sequence, or in a combination. The authors investigate alginate beads as embolic bodies and screen alginate type and bead production parameters as factors to control activity of the immobilized enzymes. Engineered embolic bodies are armed with bi-enzymatic EPT such that two enzymes perform biosynthesis of drugs with an independent control over each enzyme. Enzymatic synthesis of nitric oxide (NO) performed by embolic bodies is accomplished herein for the first time and is fine-tuned such that flux of NO afforded by the beads matches that of healthy human endothelium. Ensuing vasodilation is illustrated ex vivo using rat mesenteric arteries. Independently, the production of SN-38 is used to control the antiproliferative effects elicited by the beads. Bi-enzymatic EPT engineered into embolic bodies thus affords opportunities for combination therapy and personalized treatment (adjusted combinations and concentrations of drugs) that go well beyond the state-of-the-art of current embolic bodies and hold much promise for biomedical applications, specifically the treatment of hepatocellular carcinoma.</style></abstract><urls><related-urls><url><style face="normal" font="default" size="100%">https://onlinelibrary.wiley.com/doi/abs/10.1002/adtp.201800023</style></url></related-urls></urls><electronic-resource-num><style face="normal" font="default" size="100%">doi:10.1002/adtp.201800023</style></electronic-resource-num></record><record><database name="Alex2018.enl" path="C:\Users\au302135\Dropbox (Depcon)\MPCL Website\literature\Alex2018.enl">Alex2018.enl</database><source-app name="EndNote" version="18.2">EndNote</source-app><rec-number>5</rec-number><foreign-keys><key app="EN" db-id="s5wdvv2szdtxxfer0t3pzdxoxewd5t9appdt">5</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Röcker, Annika E.</style></author><author><style face="normal" font="default" size="100%">Müller, Janis A.</style></author><author><style face="normal" font="default" size="100%">Dietzel, Erik</style></author><author><style face="normal" font="default" size="100%">Harms, Mirja</style></author><author><style face="normal" font="default" size="100%">Krüger, Franziska</style></author><author><style face="normal" font="default" size="100%">Heid, Christian</style></author><author><style face="normal" font="default" size="100%">Sowislok, Andrea</style></author><author><style face="normal" font="default" size="100%">Riber, Camilla Frich</style></author><author><style face="normal" font="default" size="100%">Kupke, Alexandra</style></author><author><style face="normal" font="default" size="100%">Lippold, Sina</style></author><author><style face="normal" font="default" size="100%">von Einem, Jens</style></author><author><style face="normal" font="default" size="100%">Beer, Judith</style></author><author><style face="normal" font="default" size="100%">Knöll, Bernd</style></author><author><style face="normal" font="default" size="100%">Becker, Stephan</style></author><author><style face="normal" font="default" size="100%">Schmidt-Chanasit, Jonas</style></author><author><style face="normal" font="default" size="100%">Otto, Markus</style></author><author><style face="normal" font="default" size="100%">Vapalahti, Olli</style></author><author><style face="normal" font="default" size="100%">Zelikin, Alexander N.</style></author><author><style face="normal" font="default" size="100%">Bitan, Gal</style></author><author><style face="normal" font="default" size="100%">Schrader, Thomas</style></author><author><style face="normal" font="default" size="100%">Münch, Jan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The molecular tweezer CLR01 inhibits Ebola and Zika virus infection</style></title><secondary-title><style face="normal" font="default" size="100%">Antiviral Research</style></secondary-title></titles><periodical><full-title><style face="normal" font="default" size="100%">Antiviral Research</style></full-title></periodical><pages><style face="normal" font="default" size="100%">26-35</style></pages><volume><style face="normal" font="default" size="100%">152</style></volume><keywords><keyword><style face="normal" font="default" size="100%">Zika virus</style></keyword><keyword><style face="normal" font="default" size="100%">Ebola virus</style></keyword><keyword><style face="normal" font="default" size="100%">Broadly active antiviral agents</style></keyword><keyword><style face="normal" font="default" size="100%">Virus inactivation</style></keyword><keyword><style face="normal" font="default" size="100%">Lipid rafts</style></keyword></keywords><dates><year><style face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style face="normal" font="default" size="100%">2018/04/01/</style></date></pub-dates></dates><isbn><style face="normal" font="default" size="100%">0166-3542</style></isbn><urls><related-urls><url><style face="normal" font="default" size="100%">http://www.sciencedirect.com/science/article/pii/S0166354217308458</style></url></related-urls><pdf-urls><url>internal-pdf://2279020676/CLR01_TOC_small.png</url></pdf-urls></urls><electronic-resource-num><style face="normal" font="default" size="100%">https://doi.org/10.1016/j.antiviral.2018.02.003</style></electronic-resource-num></record><record><database name="Alex2018.enl" path="C:\Users\au302135\Dropbox (Depcon)\MPCL Website\literature\Alex2018.enl">Alex2018.enl</database><source-app name="EndNote" version="18.2">EndNote</source-app><rec-number>4</rec-number><foreign-keys><key app="EN" db-id="s5wdvv2szdtxxfer0t3pzdxoxewd5t9appdt">4</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Winther, Anna K.</style></author><author><style face="normal" font="default" size="100%">Fejerskov, Betina</style></author><author><style face="normal" font="default" size="100%">ter Meer, Marja</style></author><author><style face="normal" font="default" size="100%">Jensen, Najah B. S.</style></author><author><style face="normal" font="default" size="100%">Dillion, Ross</style></author><author><style face="normal" font="default" size="100%">Schaffer, Jeremy E.</style></author><author><style face="normal" font="default" size="100%">Chandrawati, Rona</style></author><author><style face="normal" font="default" size="100%">Stevens, Molly M.</style></author><author><style face="normal" font="default" size="100%">Schultze Kool, Leo J.</style></author><author><style face="normal" font="default" size="100%">Simonsen, Ulf</style></author><author><style face="normal" font="default" size="100%">Zelikin, Alexander N.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Enzyme Prodrug Therapy Achieves Site-Specific, Personalized Physiological Responses to the Locally Produced Nitric Oxide</style></title><secondary-title><style face="normal" font="default" size="100%">ACS Applied Materials &amp; Interfaces</style></secondary-title></titles><periodical><full-title><style face="normal" font="default" size="100%">ACS Applied Materials &amp; Interfaces</style></full-title></periodical><pages><style face="normal" font="default" size="100%">10741-10751</style></pages><volume><style face="normal" font="default" size="100%">10</style></volume><number><style face="normal" font="default" size="100%">13</style></number><dates><year><style face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style face="normal" font="default" size="100%">2018/04/04</style></date></pub-dates></dates><publisher><style face="normal" font="default" size="100%">American Chemical Society</style></publisher><isbn><style face="normal" font="default" size="100%">1944-8244</style></isbn><urls><related-urls><url><style face="normal" font="default" size="100%">https://doi.org/10.1021/acsami.8b01658</style></url></related-urls><pdf-urls><url>internal-pdf://3650623604/localNO2_TOC_small.png</url></pdf-urls></urls><electronic-resource-num><style face="normal" font="default" size="100%">10.1021/acsami.8b01658</style></electronic-resource-num></record><record><database name="Alex2018.enl" path="C:\Users\au302135\Dropbox (Depcon)\MPCL Website\literature\Alex2018.enl">Alex2018.enl</database><source-app name="EndNote" version="18.2">EndNote</source-app><rec-number>3</rec-number><foreign-keys><key app="EN" db-id="s5wdvv2szdtxxfer0t3pzdxoxewd5t9appdt">3</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Zuwala, Kaja</style></author><author><style face="normal" font="default" size="100%">Riber, Camilla F.</style></author><author><style face="normal" font="default" size="100%">Løvschall, Kaja Borup</style></author><author><style face="normal" font="default" size="100%">Andersen, Anna H. F.</style></author><author><style face="normal" font="default" size="100%">Sørensen, Lise</style></author><author><style face="normal" font="default" size="100%">Gajda, Paulina</style></author><author><style face="normal" font="default" size="100%">Tolstrup, Martin</style></author><author><style face="normal" font="default" size="100%">Zelikin, Alexander N.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Macromolecular prodrugs of ribavirin: Polymer backbone defines blood safety, drug release, and efficacy of anti-inflammatory effects</style></title><secondary-title><style face="normal" font="default" size="100%">Journal of Controlled Release</style></secondary-title></titles><periodical><full-title><style face="normal" font="default" size="100%">Journal of Controlled Release</style></full-title></periodical><pages><style face="normal" font="default" size="100%">53-66</style></pages><volume><style face="normal" font="default" size="100%">275</style></volume><keywords><keyword><style face="normal" font="default" size="100%">Antiviral</style></keyword><keyword><style face="normal" font="default" size="100%">Macrmolecular prodrug</style></keyword><keyword><style face="normal" font="default" size="100%">Albumin</style></keyword><keyword><style face="normal" font="default" size="100%">Drug release</style></keyword></keywords><dates><year><style face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style face="normal" font="default" size="100%">2018/04/10/</style></date></pub-dates></dates><isbn><style face="normal" font="default" size="100%">0168-3659</style></isbn><urls><related-urls><url><style face="normal" font="default" size="100%">http://www.sciencedirect.com/science/article/pii/S0168365918300725</style></url></related-urls></urls><electronic-resource-num><style face="normal" font="default" size="100%">https://doi.org/10.1016/j.jconrel.2018.02.012</style></electronic-resource-num></record></records></xml>