<?xml version="1.0" encoding="UTF-8" ?><xml><records><record><database name="Alex2010.enl" path="Z:\MPCL\public_html\wp-content\plugins\mpcl-shortcodes\Alex2010.enl">Alex2010.enl</database><source-app name="EndNote" version="15.0">EndNote</source-app><rec-number>1</rec-number><foreign-keys><key app="EN" db-id="2zdzpzdr8twxf1eavznxep0r9dfftzxsez00">1</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Zelikin, A. N.</style></author><author><style face="normal" font="default" size="100%">Städler, B.</style></author><author><style face="normal" font="default" size="100%">Price, A. D.</style></author></authors></contributors><auth-address><style face="normal" font="default" size="100%">Interdisciplinary Nanoscience Centre (INano), Aarhus University, Aarhus C 8000, Denmark&#xD;Department of Chemistry, Aarhus University, Aarhus C 8000, Denmark&#xD;Department of CINT S Cience, Sandia National Laboratories, Albuquerque, NM 87185, United States&#xD;Department of Chemical Engineering, University of Melbourne, Parkville 3010, Australia</style></auth-address><titles><title><style face="normal" font="default" size="100%">Poly(methacrylic acid) polymer hydrogel capsules: Drug carriers, sub-compartmentalized microreactors, artificial organelles</style></title><secondary-title><style face="normal" font="default" size="100%">Small</style></secondary-title></titles><periodical><full-title><style face="normal" font="default" size="100%">Small</style></full-title></periodical><pages><style face="normal" font="default" size="100%">2201-2207</style></pages><volume><style face="normal" font="default" size="100%">6</style></volume><number><style face="normal" font="default" size="100%">20</style></number><keywords><keyword><style face="normal" font="default" size="100%">cell mimics</style></keyword><keyword><style face="normal" font="default" size="100%">drug delivery</style></keyword><keyword><style face="normal" font="default" size="100%">microreactors</style></keyword><keyword><style face="normal" font="default" size="100%">polymer hydrogel capsules</style></keyword><keyword><style face="normal" font="default" size="100%">Biomedical applications</style></keyword><keyword><style face="normal" font="default" size="100%">Candidate materials</style></keyword><keyword><style face="normal" font="default" size="100%">Carrier vessels</style></keyword><keyword><style face="normal" font="default" size="100%">Diverse applications</style></keyword><keyword><style face="normal" font="default" size="100%">Drug carrier</style></keyword><keyword><style face="normal" font="default" size="100%">Micro reactor</style></keyword><keyword><style face="normal" font="default" size="100%">Multi-layered</style></keyword><keyword><style face="normal" font="default" size="100%">Poly (methacrylic acid)</style></keyword><keyword><style face="normal" font="default" size="100%">Polymer capsules</style></keyword><keyword><style face="normal" font="default" size="100%">Polymer hydrogels</style></keyword><keyword><style face="normal" font="default" size="100%">Proof of concept</style></keyword><keyword><style face="normal" font="default" size="100%">Targeted drug delivery</style></keyword><keyword><style face="normal" font="default" size="100%">Acids</style></keyword><keyword><style face="normal" font="default" size="100%">Catalysis</style></keyword><keyword><style face="normal" font="default" size="100%">Chemical reactors</style></keyword><keyword><style face="normal" font="default" size="100%">Functional polymers</style></keyword><keyword><style face="normal" font="default" size="100%">Polymers</style></keyword><keyword><style face="normal" font="default" size="100%">Hydrogels</style></keyword></keywords><dates><year><style face="normal" font="default" size="100%">2010</style></year><pub-dates><date><style face="normal" font="default" size="100%">2</style></date></pub-dates></dates><isbn><style face="normal" font="default" size="100%">16136810 (ISSN)</style></isbn><abstract><style face="normal" font="default" size="100%">Multilayered polymer capsules attract significant research attention and are proposed as candidate materials for diverse biomedical applications, from targeted drug delivery to microencapsulated catalysis and sensors. Despite tremendous efforts, the studies which extend beyond proof of concept and report on the use of polymer capsules in drug delivery are few, as are the developments in encapsulated catalysis with the use of these carriers. In this Concept article, the recent successes of poly(methacrylic acid) hydrogel capsules as carrier vessels for delivery of therapeutic cargo, creation of microreactors, and assembly of sub-compartmentalized cell mimics are discussed. The developed technologies are outlined, successful applications of these capsules are highlighted, capsules properties which contribute to their performance in diverse applications are discussed, and further directions and plausible developments in the field are suggested. © Copyright 2010 WILEY-VCH Verlag GmbH &amp; Co. KGaA, Weinheim.</style></abstract><notes><style face="normal" font="default" size="100%">Cited By (since 1996): 14&#xD;Export Date: 12 July 2012&#xD;Source: Scopus&#xD;Language of Original Document: English&#xD;Correspondence Address: Zelikin, A. N.; Interdisciplinary Nanoscience Centre (INano), Aarhus University, Aarhus C 8000, Denmark; email: zelikin@chem.au.dk&#xD;References: Zelikin, A.N., (2010) ACS Nano, 4, p. 2494; De Geest, B.G., Sanders, N.N., Sukhorukov, G.B., Demeester, J., De Smedt, S.C., (2007) Chem. Soc. Rev., 36, p. 636; Quinn, J.F., Johnston, A.P.R., Such, G.K., Zelikin, A.N., Caruso, F., (2007) Chem. Soc. Rev., 36, p. 707; Hammond, P.T., (2004) Adv. Mater., 16, p. 1271; Boudou, T., Crouzier, T., Ren, K.F., Blin, G., Picart, C., (2010) Adv. Mater., 22, p. 441; Reibetanz, U., Claus, C., Typlt, E., Hofmann, J., Donath, E., (2006) Macromol. Biosci., 6, p. 153; Zhao, Q.H., Han, B.S., Wang, Z.H., Gao, C.Y., Peng, C.H., Shen, J.C., (2007) Nanomed. 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Mater., 18, p. 328</style></notes><urls><related-urls><url><style face="normal" font="default" size="100%">http://www.scopus.com/inward/record.url?eid=2-s2.0-78349251345&amp;partnerID=40&amp;md5=08ab6a1a0dc5c6bdc4e52e4a3a979425</style></url></related-urls><pdf-urls><url>internal-pdf://PMA_capsules-1052316442/PMA_capsules.png</url></pdf-urls></urls><electronic-resource-num><style face="normal" font="default" size="100%">10.1002/smll.201000765</style></electronic-resource-num></record><record><database name="Alex2010.enl" path="Z:\MPCL\public_html\wp-content\plugins\mpcl-shortcodes\Alex2010.enl">Alex2010.enl</database><source-app name="EndNote" version="15.0">EndNote</source-app><rec-number>2</rec-number><foreign-keys><key app="EN" db-id="2zdzpzdr8twxf1eavznxep0r9dfftzxsez00">2</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Zelikin, A. N.</style></author></authors></contributors><auth-address><style face="normal" font="default" size="100%">Department of Chemistry, Interdisciplinary Nanoscience Center (INANO), Aarhus University, Aarhus C 8000, Denmark</style></auth-address><titles><title><style face="normal" font="default" size="100%">Drug releasing polymer thin films: New era of surface-mediated drug delivery</style></title><secondary-title><style face="normal" font="default" size="100%">ACS Nano</style></secondary-title></titles><periodical><full-title><style face="normal" font="default" size="100%">ACS Nano</style></full-title></periodical><pages><style face="normal" font="default" size="100%">2494-2509</style></pages><volume><style face="normal" font="default" size="100%">4</style></volume><number><style face="normal" font="default" size="100%">5</style></number><keywords><keyword><style face="normal" font="default" size="100%">Cell adhesion</style></keyword><keyword><style face="normal" font="default" size="100%">Drug delivery</style></keyword><keyword><style face="normal" font="default" size="100%">Gene transfer</style></keyword><keyword><style face="normal" font="default" size="100%">Polymers</style></keyword><keyword><style face="normal" font="default" size="100%">Sequential deposition</style></keyword><keyword><style face="normal" font="default" size="100%">Thin films</style></keyword><keyword><style face="normal" font="default" size="100%">Biomedical applications</style></keyword><keyword><style face="normal" font="default" size="100%">Fouling behavior</style></keyword><keyword><style face="normal" font="default" size="100%">Polymer deposition</style></keyword><keyword><style face="normal" font="default" size="100%">Polymer thin films</style></keyword><keyword><style face="normal" font="default" size="100%">Practical solutions</style></keyword><keyword><style face="normal" font="default" size="100%">Proof of concept</style></keyword><keyword><style face="normal" font="default" size="100%">Surface coatings</style></keyword><keyword><style face="normal" font="default" size="100%">Tissue response</style></keyword><keyword><style face="normal" font="default" size="100%">Adhesion</style></keyword><keyword><style face="normal" font="default" size="100%">Biological materials</style></keyword><keyword><style face="normal" font="default" size="100%">Deposition</style></keyword><keyword><style face="normal" font="default" size="100%">Functional polymers</style></keyword><keyword><style face="normal" font="default" size="100%">Plastic coatings</style></keyword><keyword><style face="normal" font="default" size="100%">Plastic films</style></keyword><keyword><style face="normal" font="default" size="100%">Polymeric films</style></keyword><keyword><style face="normal" font="default" size="100%">Surface properties</style></keyword><keyword><style face="normal" font="default" size="100%">Trace analysis</style></keyword><keyword><style face="normal" font="default" size="100%">Polymer films</style></keyword><keyword><style face="normal" font="default" size="100%">biopolymer</style></keyword><keyword><style face="normal" font="default" size="100%">drug carrier</style></keyword><keyword><style face="normal" font="default" size="100%">polymer</style></keyword><keyword><style face="normal" font="default" size="100%">animal</style></keyword><keyword><style face="normal" font="default" size="100%">cell proliferation</style></keyword><keyword><style face="normal" font="default" size="100%">chemistry</style></keyword><keyword><style face="normal" font="default" size="100%">drug delivery system</style></keyword><keyword><style face="normal" font="default" size="100%">drug effect</style></keyword><keyword><style face="normal" font="default" size="100%">human</style></keyword><keyword><style face="normal" font="default" size="100%">metabolism</style></keyword><keyword><style face="normal" font="default" size="100%">methodology</style></keyword><keyword><style face="normal" font="default" size="100%">review</style></keyword><keyword><style face="normal" font="default" size="100%">surface property</style></keyword><keyword><style face="normal" font="default" size="100%">Animals</style></keyword><keyword><style face="normal" font="default" size="100%">Biopolymers</style></keyword><keyword><style face="normal" font="default" size="100%">Drug Carriers</style></keyword><keyword><style face="normal" font="default" size="100%">Drug Delivery Systems</style></keyword><keyword><style face="normal" font="default" size="100%">Humans</style></keyword></keywords><dates><year><style face="normal" font="default" size="100%">2010</style></year><pub-dates><date><style face="normal" font="default" size="100%">1</style></date></pub-dates></dates><isbn><style face="normal" font="default" size="100%">19360851 (ISSN)</style></isbn><abstract><style face="normal" font="default" size="100%">Polymer films and coatings are among the popular and most successful tools to modulate surface properties of biomaterials, specifically tissue responses and fouling behavior. Over the past decade, a novel opportunity has been widely investigated, namely utility of surface coatings in surface-mediated drug delivery. In these applications, deposited polymer films act as both a coating to modulate surface properties and a reservoir for active therapeutic cargo. The field has recently accelerated beyond the proof-of-concept reports toward delivering practical solutions and established technologies for biomedical applications. This review briefly summarizes the recent successes of polymer thin films, specifically those constructed by sequential polymer deposition technique, in surface-mediated drug delivery. © 2010 American Chemical Society.</style></abstract><notes><style face="normal" font="default" size="100%">Cited By (since 1996): 36&#xD;Export Date: 12 July 2012&#xD;Source: Scopus&#xD;PubMed ID: 20423067&#xD;Language of Original Document: English&#xD;Correspondence Address: Zelikin, A. N.; Department of Chemistry, Interdisciplinary Nanoscience Center (INANO), Aarhus University, Aarhus C 8000, Denmark; email: zelikin@chem.au.dk&#xD;Chemicals/CAS: Biopolymers; Drug Carriers; Polymers&#xD;References: Acharya, G., Park, K., Mechanisms of controlled drug release from drug-eluting stents (2006) Adv. Drug Delivery Rev., 58, pp. 387-401; Tessmar, J.K., Gopferich, A.M., Matrices and scaffolds for protein delivery in tissue engineering (2007) Adv. Drug Delivery Rev., 59, pp. 274-291; Cao, L., Mooney, D.J., Spatiotemporal control over growth factor signaling for therapeutic neovascularization (2007) Adv. Drug Delivery Rev., 59, pp. 1340-1350; Place, E.S., Evans, N.D., Stevens, M.M., Complexity in biomaterials for tissue engineering (2009) Nat. Mater., 8, pp. 457-470; Stevens, M.M., George, J.H., Exploring and engineering the cell surface interface (2005) Science, 310, pp. 1135-1138; Saltzman, W.M., Olbricht, W.L., Building drug delivery into tissue engineering (2002) Nat. Rev. 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